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KMID : 1234420090370020133
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Korean Journal of Microbiololgy and Biotechnology
2009 Volume.37 No. 2 p.133 ~ p.139
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Evaluation of Antimicrobial, Antithrombin, and Antioxidant Activity of Dioscorea batatas Decne
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Kim Jee-In
Jang Han-Su
Kim Jong-Sik
Sohn Ho-Yong
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Abstract
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Yam (Dioscorea batatas Decne) has been recognized as healthy food due to its various biological activities, such as anti-obesity, anti-constipation, anti-proliferation, anti-mutagenic activity, and decrease of blood glucose and cholesterol level. In this study, the methanol extract and its organic solvent fractions were prepared from dried Dioscorea batatas Decne, and their antimicrobial, antithrombin, and antioxidant activity were evaluated, respectively. The 66.7% of methanol extract was fractioned into water residue, and most of total-polyphenol/total-flavonoids were found in ethylacetate fraction. This ethylacetate fraction at 500 μg/disc concentration showed strong antibacterial activity against gram-negative and gram-positive bacteria, except Staphylococcus aureus. Antifungal activity was not observed in methanol extract and its fractions. But, strong antithrombin activity was found in methanol extract. At 4.8 mg/mL concentration, thrombin time was 99.5 sec, which is coincides with 30% activity of aspirin, a commercial available antithrombosis agent. The ethylacetate fraction showed strong DPPH scavenging activity (IC50 of 80.5 μg/mL), compared to vitamin C (IC50 of 15.2 μg/mL). Also, the ethylacetate fraction showed strong SOD-like activity and reducing power, which are coincide with 43% of vitamin C and 82.7% of butylated hydroxytoluene activity, respectively.
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KEYWORD
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Antimicrobial, antioxidant, antithrombosis, Dioscorea batatas Decne, Yam
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